APOEe2 is associated with milder clinical and pathological Alzheimer
disease
 
   Lead Investigator:    Brad Hyman
   Institution      :    Mass ADRC
   E-Mail           :    bhyman@partners.org
   Proposal ID      :    468


   Publications:


1  Serrano-Pozo A, Qian J,  Monsell S , Betensky R, Hyman B
   APOE2 is associated with milder clinical and pathological Alzheimer's disease
   Abstract  Neurology,84:S16.005,2015,

   PUBLISHED



2  Serrano-Pozo A, Qian J,  Monsell S , Betensky R, Hyman B
   APOEepsilon2 is associated with milder clinical and pathological Alzheimer disease
   Journal Article  Ann Neurol,77:917-929,2015,PMC4447539

   PUBLISHED





   Proposal Description:
   The Alzheimer disease APOEe4 risk allele associates with an earlier age of onset and increased amyloid plaque deposition, whereas the protective APOEe2 allele delays the age of onset and appears to prevent amyloid-beta deposition. Yet the clinical and pathological effects of APOEe2 have not been well established because of its relative rarity. We will investigate the effects of APOEe4 and e2 alleles on AD pathology and cognition.